Information

Tender reference number	OC/EFSA/IDATA/2022/01
Title	Implementation of a Multi-OMICs and Inter-species Workflow to Derive Human Reference Points and Health-based Guidance Values (HBGVs) from Quantitative in Vitro Data
Description	The overarching goal of the project is to define, validate and apply a standardised workflow (experimental and computational) for deriving reliable human reference points and HBGVs using cutting edge in-vitro approaches, namely organ-on-a-chip (OoC) platforms and multiple OMICs endpoints (transcriptomics, metabolomics, epigenomics).
Contract type	Services
Procedure type	Open procedure
Status	Closed
Published on TED
Submission Method	Electronic
Tenders may be submitted	All lots
Maximum number of lots	2
Information about a public contract, a framework agreement or a dynamic purchasing system (DPS)	Public contract
Address of the buyer profile: (URL)	http://www.efsa.europa.eu/en/procurement/tenders.htm
Estimated total value	3250000.00 EUR
Main CPV	73000000

Conditions for participation

Suitability to pursue the professional activity, including requirements relating to enrolment on professional or trade registers	As stated in the procurement documents.
Economic and financial standing - List and brief description of selection criteria	Selection criteria as stated in the procurement documents
Economic and financial standing- Minimum level(s) of standards possibly required	Selection criteria as stated in the procurement documents
Technical and professional ability - List and brief description of selection criteria	Selection criteria as stated in the procurement documents
Technical and professional ability - Minimum level(s) of standards possibly required	Selection criteria as stated in the procurement documents

Milestones

TED publication date	28/03/2022 00:00
Question deadline	07/06/2022 14:30 UTC+02:00
Answer deadline	09/06/2022 23:59 UTC+02:00
Time limit for receipt of tenders	15/06/2022 14:30 UTC+02:00
Conditions for opening tenders (date)	16/06/2022 14:30 UTC+02:00

Lots

Lot number	Title	Description
Lot 1	Implementation of a Multi-OMICs and Inter-species Workflow (Objective 1)	• Objective 1: Implementation of a multi-OMICs and inter-species workflow. In phase one, a set of data-rich substances will be selected (6 to 12 compounds) and used for an extensive toxicological screening based on OoC and multi-OMICs profiling (transcriptomics, epigenomics, metabolomics). Selected substances will include legacy hazards in food/feed and compounds/nutrients with positive health claims (e.g. resveratrol, to be used to verify applicability of OMICs in assessing beneficial dietary effects). The experimental design will be largely based on the procedures established in EU ToxRisk.
Lot 2	Lot 2 – Inference of Chemical Grouping from Processed OMICS Data in CTD (Objective 2)	• Objective 2: Inference of chemical grouping from processed OMICS data in the comparative toxicogenomics database (CTD).

Notices

Reference	Notice type	Publication date
2022/S 061-159288	Contract notice	28/03/2022 00:00